BT204: CancerMine: Knowledge base construction for personalised cancer treatment
|Title||BT204: CancerMine: Knowledge base construction for personalised cancer treatment|
|Publication Type||Conference Paper|
|Year of Publication||2016|
|Authors||Lever J, Jones M, Jones SJm|
|Conference Name||International Conference on Biomedical Ontology and BioCreative (ICBO BioCreative 2016)|
|Publisher||CEUR-ws.org Volume 1747|
Knowledge of the relevant genomic aberrations that drive a particular cancer type is necessary to accelerate efficient interpretation of genomic data and enable large-scale endeavors in precision medicine. Currently, this field is limited by the lack of focused and scalable literature curation tools that can reliably capture the required information. Here we present a knowledge-base of genes that have been described in the literature as drivers, oncogenes or tumour suppressors with respect to a specific type of cancer. We have annotated a large body of literature which reports oncogenic aberrations using a custom designed annotation tool. We then applied VERSE, an in-house relation extraction tool, to catalogue driver mutations and illustrate the ability to build a useful resource for clinical interpretation of genomic data for personalized treatment approaches.