IP03: Multi-species Ontologies of the Craniofacial Musculoskeletal System
|Title||IP03: Multi-species Ontologies of the Craniofacial Musculoskeletal System|
|Publication Type||Conference Paper|
|Year of Publication||2016|
|Authors||Mejino JL, Brinkley J, Cox T, Detwiler L|
|Conference Name||International Conference on Biomedical Ontology and BioCreative (ICBO BioCreative 2016)|
|Publisher||CEUR-ws.org Volume 1747|
We created the Ontology of Craniofacial Development and Malformation (OCDM)  to provide a unifying framework for organizing and integrating craniofacial data ranging from genes to clinical phenotypes from multi-species. Within this framework we focused on spatio-structural representation of anatomical entities related to craniofacial development and malformation, such as craniosynostosis and midface hypoplasia. Animal models are used to support human studies and so we built multi-species ontologies that would allow for cross-species correlation of anatomical information. For this purpose we first developed and enhanced the craniofacial component of the human musculoskeletal system in the Foundational Model of Anatomy Ontology (FMA), and then imported this component, which we call the Craniofacial Human Ontology (CHO), into the OCDM. The CHO was then used as a template to create the anatomy for the mouse, the Craniofacial Mouse Ontology (CMO) as well as for the zebrafish, the Craniofacial Zebrafish Ontology (CZO).